The Peroni company was established under the founding family name in the town of Vigevano, Italy, in 1846. Business boomed and a second brewery was built in Rome. The company was moved to Rome by Giovanni Peroni in 1864, just six years prior to Rome becoming the Italian capital in 1870.

Throughout the late 19th and early 20th centuries, the company became one of the most prominent brewing companies in the newly unified Italian nation.